Support for Clearer Skin

Nicomide® contains high levels of niacinamide and zinc that help keep the follicle clear to promote healthier skin.1-9

  • Rich source of niacinamide and zinc10
  • Niacinamide is a water-soluble B-vitamin that can therefore be readily excreted in urine11,12
  • Added benefits of folic acid, copper, selenium, and chromium10

Nicomide® is a non-drug vitamin and mineral dietary supplement in an easy-to-take oral tablet.

Nicomide® provides an effective and well-tolerated vitamin + mineral formula.1-9
Nicomide® is formulated to address the specific nutritional deficiencies that are associated with skin irritation and inflammation.2-8,13-17

Nicomide® provides key nutrients that may help to better moderate the cellular processes that lead to dermal irritation and inflammation.2-8,13-17

Niacinamide and zinc in Nicomide® may help moderate inflammatory acne by the following mechanisms:

  • Inhibit leukocytic chemotaxis2-5,13-16
  • Inhibit lysosomal enzyme release2-5,13-17
  • Inhibit lymphocytic transformation3,13-15
  • Inhibit mast cell degranulation3,6,7,13-15,17
  • Inhibit P. acnes lipase activity 5,6,8,13

WARNINGS: If you are pregnant, nursing, or taking medication, consult your doctor before use. Use only under the advice and supervision of a physician if you have a history of jaundice, liver disease or diabetes. Abnormal liver functions have been reported in persons taking daily doses of 500 mg or more of niacinamide. Folate intake should not exceed 250% of the Daily Value (1,000 mcg).

NICOMIDE® CONTAINS L-METHYLFOLATE CALCIUM. THE L-METHYLFOLATE ([6S]-N5-METHYLTETRAHYDROFOLIC ACID CALCIUM SALT) IN NICOMIDE® IS LESS THAN 1.0% D-ISOMER.

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE. KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.

Click here for important safety information.

    REFERENCES:

  1. . Natural Medicines Comprehensive Database Consumer Version. Niacin and niacinamide (Vitamin B3). National Institutes of Health MedlinePlus Website. https://medlineplus.gov/druginfo/natural/1534.html. Reviewed August 21, 2014. Accessed December 18, 2014.
  2. . Fivenson, D, ‘The Mechanism of Action of Nicotinamide and Zinc in Inflammatory Skin Diseases’, 77 ( 1S ): Cutis. 2006; 5 – 10.
  3. . Shalita A, Smith G, Parish L, Sofman M, Chalker D ‘Topical Nicotinamide Compared with Clindamycin Gel in the Treatment of Inflammatory Acne Vulgaris’, 34 ( 6 ): International Journal of Dermatology. 1995; 434 – 437.
  4. . Cunliffe, W , Burke B, Dodman B ‘A double-blind trial of a zinc sulphate/citrate complex and tetracycline in the treatment of acne vulgaris’,101 ( 3 ): British Journal of Dermatology. 1979; 321 – 325.
  5. . Cassano, N, Amoruso A, Vena GA ‘Zinc Nutritive and Skin: An Overview’ , 20 ( ): Journal of Applied Cosmetol. 2002; 183 – 193.
  6. . Schwartz, J , Marsh R, Draelos Z ‘Zinc and Skin Health: Overview of Physiology and Pharmacology’, 31 ( 7 ): Dermatol Surg. 2005; 837 – 847.
  7. . Michaelsson, A , Juhiln L, Vahlquist A ‘Effects of Oral Zinc and Vitamin A in Acne’, 113 (1): Arch Dermatol. 1977; 31 – 36.
  8. . Higaki, S, ‘Lipase Inhibitors for the treatment of acne’, 22 ( ): Journal of Molecular Catalysis B Enzymatic 2003; 377 – 384.
  9. . Webster GF. Inflammation in acne vulgaris. J Am Acad Dermatol.1995; 33(2):247–253.
  10. . Nicomide Prescribing Information, Avion Pharmaceuticals, November 2017.
  11. . National Center for Biotechnology Information. PubChem Compound Database; CID=936. https://pubchem.ncbi.nlm.nih.gov/compound/936. Accessed Feb. 9, 2018.
  12. . Chemicalland21. Niacinamide. Website.
    http://www.chemicalland21.com/lifescience/foco/NIACINAMIDE.htm. Accessed
    February 9, 2018.
  13. . Wolverton, S, Comprehensive Dermatologic Drug Therapy Edinburgh, London, New York, Oxford, Philadelphia, St Louis, Sydney, Toronto 2013 : 3rd ed, Vol 2013.
  14. . Niren, N , ‘Pharmacologic Doses of Nicotinamide in the Treatment of Inflammatory Skin Conditions A Review’, 77 ( 1S ): Cutis. 2006; 11 – 16.
  15. . Namazi, M, ‘Nicotinamide: a potential addition to the anti-psoriatic weaponry’, 17 (11): The FASEB Journal – Federation of American Societies for Experimental Biology. 2003; 1377 – 1379.
  16. . Dreno, B , Amblard P, Agache P ‘Low Doses of Zinc Gluconate for Inflammatory Acne’, 6 ( 69 ): Acta Derm Venerol. 1989; 541 – 543.
  17. . Berk, M , Lorinez A ‘The Treatment of Bullous Pemphigoid With Tetracycline and Niacinamide’, 122 (): Archives Dermatology. 1986; 670 – 674.

*Most eligible patients will pay no more than $25 for each fill. For Nicomide® the maximum benefit is $100 per fill. Patient will be responsible for any additional money due.